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6 courses found. Showing results 1–6.
- MLS-M 388 Digital Biology: A Survey of Topics in Bioinformatics and Functional Genomics (3 cr.) P: BIOL-L 211 or BIOL-S 211; or consent of instructor. Bioinformatics covers a wide spectrum of data management, processing and analysis associated with high throughput biological data. Course considers the generation and analysis of biomolecular sequence data describing DNA and proteins that underpin modern biology, including fields such as genetics, evolution and structural biology. Credit given for one of BIOL-L 388 or MLS-M 388.
- MLS-M 410 Protein Metabolism (3 cr.) P: BIOL-L 211 or BIOL-S 211. Focuses on the mechanisms and enzymes that synthesize, fold, traffic and degrade proteins. Provides a molecular and structural view of key processes such as translation, folding, membrane insertion, vesicular trafficking, post-translational modification and protein degradation. Emphasizes broader principles such as NTP switches as regulators and macromolecular interaction events; explains how cellular architecture underpins function. Describes structural and mechanistic features of protein metabolism in a cellular context.
- MLS-M 420 Genome Duplication and Maintenance (3 cr.) P: BIOL-L 211 or BIOL-S 211. Examines genomic structure, DNA topology and replication mechanisms in the context of cell function for all three domains of life. Studies the pathological consequences of failure to duplicate and maintain the genome.
- MLS-M 430 Advanced Gene Regulation: Transcription, Epigenetics, and Human Disease (3 cr.) P: BIOL-L 211 or BIOL-S 211. Considers mechanistic, structural and regulatory aspects of the process by which information coded in DNA is transcribed into messenger and structural RNAs. Investigates the role of post-translational modification on nucleosome tails and on the RNA polymerase itself to regulate the timing and extent of transcription. Examines how regulatory marks are written and interpreted.
- MLS-M 440 Membranes and Signal Transduction (3 cr.) P: BIOL-L 211 or BIOL-S 211. Provides a detailed introduction to membrane physiology from a structural and mechanistic perspective. Considers membranes and membrane-embedded proteins that serve as barriers and gatekeepers to regulate material flow in and out of cells and organelles, act as a capacitor to support chemical energy synthesis, and support signal transduction to respond to environmental cues.
- MLS-M 450 Molecular Mechanisms of Cancer (3 cr.) P: BIOL-L 211 or BIOL-S 211. Focuses on the molecular basis of genome instability, including factors that lead to tumorigenesis and tumor suppression. Studies the action mechanisms and disease relevance of key enzymes, along with available and emerging treatments for cancer.